Patients with intensive treatment had a lower multivariable-adjusted subdistribution hazard ratio for the primary outcome, but with a wide overlap of 95%CI. Overall, the risk of the primary outcome rose as the cumulative uric acid concentration increased in both the intensive and standard treatment groups. We also examined the change in the follow-up uric acid concentrations. In the analysis of all-cause death, the Cox regression model was used. This post hoc analysis was performed to examine whether the effects of intensive SBP intervention differed by the baseline uric acid concentration using 2 models: restricted cubic spline curves and subgroup analyses, both based on the Fine-Gray subdistribution hazard model in the analysis of the primary outcome and secondary outcomes (excluding all-cause death). The primary outcome was a composite of cardiovascular disease events. The STEP trial was a randomized controlled trial that compared the effects of intensive (SBP target of 110 to < 130 mmHg) and standard (SBP target of 130 to < 150 mmHg) SBP control in Chinese patients aged 60 to 80 years with hypertension. Whether the serum uric acid concentration at baseline alters the benefits of intensive SBP control is unknown. Do let us know how you get on with it too.Intensive systolic blood pressure (SBP) control improved outcomes in the Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial. If you would like to find out more and try out the public beta then go to the Nugen Audio web site and check it out. By ‘sampling’ the vocal and applying the inverted the curve to the backing, specific space can be gently created without unnecessarily altering the original tonality of the underlying audio. The EQ Invert control gives you a minimally-invasive technique for creating space in a complex mix where traditional EQs are just too cumbersome. Or use the same technique on individual tracks to unify different takes, microphone positions, and more. Match One Recording To Anotherīeyond traditional EQ, you can also use SEQ-S to capture the flavour of a piece of source audio and then transfer it to your current work – great for restoration and harmonisation work. Couple this with EQ matching via sonic fingerprinting and you have some unique possibilities. Massage and correct any audio with incredible resolution that you just can’t get with a traditional parametric interface.Ī direct-draw interface and detailed spectrum analysis make it easy to quickly identify and specifically fine-tune your audio. The SEQ-S has stereo mid-side operation and automated spectrum analysis. This is what they say about it… Nugen Audio SEQ-S with sonic sculpting and EQ matching up to 7.1 They have been busy testing it between the scenes and now would like offer it as a public beta for further testing. Have you have two clips of the same person recorded at different times and wanted to match them? Well our friends at Nugen Audio have been working very hard developing a plug-in that would help with this task. SEQ-S is available now and there is more information about SEQ-S on the Nugen Audio website. We will be making a Show & Tell video review of the SEQ-s very soon. In a typical music project, by “sampling” the vocal and then using the EQ invert button to apply the inverted curve to the backing, users can gently create specific space without unnecessarily damaging the original tonality of the underlying audio. In addition, SEQ-S’s EQ invert button provides a subtle technique for creating space in a complex mix, a task that can be too cumbersome with a traditional EQ. When coupled with EQ matching via sonic fingerprinting the plug-in can offer the option to match one recording to another to capture the “flavour” of a piece of source audio and then transfer it to the current project. Through SEQ-S’s direct-draw interface and spectrum analysis, users can identify and fine-tune their audio. SEQ-S also includes a unique resolution setting that can be used with high precision in the low frequencies, allowing for highly transparent adjustments without muddying the mix. With SEQ-S, unlike many digital EQs, the SEQ-S features a phase profile that is linear across the frequency spectrum, which results in natural-sounding EQ changes and produces minimal phase artifacts. Jon Schorah, creative director at NUGEN Audio told us… With support for mono, stereo, 5.1, and 7.1 surround, SEQ-S provides sonic sculpting and precision EQ matching including stereo mid-side operation, automated spectrum analysis, curve smoothing, and a direct-draw spline interface for corrective applications. Nugen Audio, have announced the launch of their new SEQ-S linear-phase equaliser for use in music production, mastering and film and post-production applications.
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